Drivers is Australia who tested positive to drugs in roadside checks have had their results confirmed in a laboratory and will be charged.
Police had to wait until Queensland Health Scientific Services analysed the drivers' saliva samples in its laboratory and confirmed the presence of drugs before they could be charged.
All 10 drivers tested positive to driving while under the influence of methamphetamine.
A 42-year-old man has been summonsed to appear in Brisbane Magistrates Court on January 31 and a 25-year-old man will appear in the same court on February 11.
Since random drug-testing of drivers was introduced on December 1, 19 drivers have tested positive to drugs, up until midnight on Thursday.
Police are still awaiting laboratory confirmation of the remaining nine test results.
Of the 19 drivers, 17 tested positive to methamphetamine, one tested positive to both methamphetamine and cannabis and one tested positive for ecstasy.
Drug-drivers can be fined up to $1050, lose their licence or face up to three months' jail.
Police hope to saliva-test about 20,000 drivers in the first year of the random roadside drug-testing operations and expect about 300 to test positive to illicit drugs.
The introduction of drug testing comes as Queensland cut its road toll by more than two-thirds for the official holiday period, with four deaths against last year's 13.
Across Australia, 45 people died on the roads this season compared with 62 last year.